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Investigation on the potential applicationof Morus alba stem extract for inflammatory acne vulgaris |
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| รหัสดีโอไอ | |
| Creator | 1. Kanyarat Srihaphon 2. Thidarat Wongwat 3. Supaporn Lamlertthon 4. Tasana Pitaksuteepong |
| Title | Investigation on the potential applicationof Morus alba stem extract for inflammatory acne vulgaris |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2563 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 42 |
| Journal No. | 6 |
| Page no. | 1319-1325 |
| Keyword | Morus alba, stem extract, acne, antibacterial, antioxidant, anti-inflammation |
| URL Website | https://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | This study was aimed to investigate the potential use of Morus alba stem extract for treatment of inflammatory acnethrough its inhibitory activities against acne-causing bacteria, free radicals, prostaglandin (PG)-E2 and tyrosinase enzyme. Theantibacterial studies found that among Propionibacterium acnes, Staphylococcus epidermidis and Staphylococcus aureus, theextract specifically inhibited P. acnes with MIC and MBC of 3.125 mg/ml and 12.5 mg/ml, respectively. It also exhibited the abilityto scavenge free radicals including DPPH, superoxide and nitric oxide radicals with IC50 values of 32.07, 67.29 and 12.12 ?g/ml,respectively. Moreover, the extract could significantly inhibit the production of PGE2, a potent inflammatory mediator.Additionally, it presented potent anti-tyrosinase activity (5.76 ? 1.58 ?g/ml) and was significantly more effective than kojic acid(30.61 ? 13.35 ?g/ml), offering great benefits to reduce post inflammatory hyperpigmentation. These findings suggest potentialapplication of the extract in cosmeceutical formulations for inflammatory acne. |
