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Proniosomes: An effective carrier for dermal and transdermal delivery |
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| รหัสดีโอไอ | |
| Creator | 1. Boontida Morakul 2. Varaporn Buraphacheep Junyaprasert |
| Title | Proniosomes: An effective carrier for dermal and transdermal delivery |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2563 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 42 |
| Journal No. | 6 |
| Page no. | 1171-1186 |
| Keyword | proniosomes, dermal delivery, transdermal delivery, application |
| URL Website | https://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | Proniosomes are non-ionic surfactant based vesicles that can be hydrated to yield an aqueous niosomal dispersion. Theevolution of proniosomes has been motivated by development of niosomes to minimise the stability problems of niosomes andliposomes. Moreover, proniosomes can encapsulate both hydrophilic and lipophilic drugs. They are effective in enhancing skinpenetration for transdermal delivery. This article describes key compositions of a proniosomal system, types of proniosomes,preparation techniques, and their characteristic properties including particle size, morphology, flow ability, entrapmentefficiency, drug release, and permeability performance. The advantages of proniosomes, the mechanism of action in skinpenetration, and the toxicity of proniosomes are discussed. Several categories of drugs formulated for a proniosomal system andtopical or transdermal delivery are also reviewed. |
