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Allele frequency of A385T in Fucosyltransferase 2 gene (FUT2)among Southern Thai population |
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| รหัสดีโอไอ | |
| Creator | 1. Darinnat Buathong 2. Thanet Prajantasen 3. Theerakamol Pengsakul |
| Title | Allele frequency of A385T in Fucosyltransferase 2 gene (FUT2)among Southern Thai population |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2563 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 42 |
| Journal No. | 5 |
| Page no. | 1021-1026 |
| Keyword | A385T, allele specific PCR, FUT2 gene, Southern Thai |
| URL Website | https://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | Fucosyltransferase 2 gene (FUT2) gene plays an important role in control of enzymes that secrete blood type antigensubstances. The mutation of FUT2 at nucleotide position 385 from A to T (A385T) combined with secretor phenotype isassociated with proneness to infections by some pathogens, on comparing with the non secretor phenotype. The objective set wasto study the prevalence of A385T mutation with secretor phenotype. Among 132 Southern Thai individuals, 18(13.6%) hadLe(a+b-) phenotype and 5(3.8%) had Le(a-b-) non secretor phenotype with genotypes AA 6(26.0%), AT 13(56.5%) and TT4(17.3%); whereas 109(82.6%) having Le(a-b+) phenotype and 7(5.3%) having a Le(a-b-) secretor phenotype had genotypes AA42(31.8%), AT 50(37.9) and TT 10(7.5%). The frequencies of genotypes AA, AT and TT among 264 alleles examined in asample of 132 Southern Thai individuals were 48, 70, and 14%, respectively, indicating a rather wide distribution of A385T inFUT2 gene in the Southern Thai population. The results show that the FUT2 gene really encodes the secretor enzyme?(1,2)fucosyltransferase and indicate an ethnic group-specific nonsense or missense point mutation in the FUT2 gene. This studyprovides substantial new information on the prevalence of the examined polymorphism. |
