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Torvoside A extracted from Solanum torvum fruits does not directlyaffect 3T3-L1 adipogenesis, adiponectin synthesis and glucose uptake |
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| รหัสดีโอไอ | |
| Creator | 1. Pilaiwan Siripurkpong 2. Mudtika Fungkrajai |
| Title | Torvoside A extracted from Solanum torvum fruits does not directlyaffect 3T3-L1 adipogenesis, adiponectin synthesis and glucose uptake |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2563 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 42 |
| Journal No. | 5 |
| Page no. | 975-983 |
| Keyword | Torvoside A, adipogenesis, glucose uptake, Solanum torvum, fat accumulation |
| URL Website | https://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | The present study was aimed to determine the effects of Torvoside A from methanolic extract of Solanum torvum onadipogenesis, fat accumulation, and adiponectin synthesis as well as glucose uptake activities. For adipogenesis assay, 3T3-L1-preadipocytes were treated with Torvoside A (0, 5, 25, 50 ?M) during 7 days of adipocyte differentiation, while 3T3-L1 matureadipocytes were treated with Torvoside A for 2 days in the fat accumulation study. There were no significant differences in theintracellular triglyceride among Torvoside A treated cells and the untreated control (p>0.05) in both assays. Torvoside A did notsignificantly change adiponectin synthesis in both transcriptional and translational levels (p>0.05), measured by real-time RTPCR and western blot, respectively. Finally, Torvoside A did not affect glucose uptake activity and GLUT4 transcript as well.These results can be concluded that Torvoside A could not directly promote adipocyte hyperplasia and hypertrophy as well as theanti-diabetic activities. |
