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Anti-oxidative, anti-inflammatory, and anti-estrogenic effectsof mushroom Mycoamaranthus cambodgensis (Pat.)Trappe, S. Lumyong, P. Lumyong, Sanmee & Zhu L. Yang extract |
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| รหัสดีโอไอ | |
| Creator | 1. Niramai Fangkrathok 2. Jintana Junlatat 3. Bungorn Sripanidkulchai 4. Orapun Jaisamut |
| Title | Anti-oxidative, anti-inflammatory, and anti-estrogenic effectsof mushroom Mycoamaranthus cambodgensis (Pat.)Trappe, S. Lumyong, P. Lumyong, Sanmee & Zhu L. Yang extract |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2563 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 42 |
| Journal No. | 4 |
| Page no. | 865-872 |
| Keyword | Mycoamaranthus cambodgensis, anti-oxidative activity, anti-estrogenic activity, anti-inflammatory activity |
| URL Website | https://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | Mycoamaranthus cambodgensis (Pat.) Trappe, S. Lumyong, P. Lumyong, Sanmee & Zhu L. Yang (Hymenogasteraceae) is a wild edible mushroom found in the deciduous forests of Thailand. It is used as a folk medicine for postpartumrecovery. This study aimed to investigate the anti-oxidative, anti-estrogenic, and anti-inflammatory activities of M. cambodgensisextract (MCE). The MCE showed high anti-oxidative activity. From the DPPH and FRAP methods, the 50% effectiveconcentrations were 55.51?3.62 ?g/mL and 166.64?11.43 ?g/mg, respectively. The extract contained high total phenolic(113.80?3.13 mg tannic acid equivalent/g) and flavonoid contents (2.61?0.12 mg quercetin equivalent/g). The MCE decreasedpro-inflammatory mediator gene expressions including COX-2, IL-1?, IL-6, iNOS, and TNF-?. In 17?-estradiol (E2)-inducedMCF-7 cells, the MCE at 12.5 ?g/mL synergistically augmented the proliferative effect of E2, whereas MCE at 50?100 ?g/mLsignificantly suppressed this E2 effect. The potent anti-oxidant content and anti-estrogenic activity of MCE may correlate to itsanti-inflammatory activity and traditional uses. This mushroom is a good candidate for further natural product development. |
