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Effects of aged garlic extract on spatial memory and oxidative damage in the brain of amyloid-? induced rats |
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| รหัสดีโอไอ | |
| Creator | 1. Thanyaporn Wichai 2. Wanassanun Pannangrong 3. JariyaUmka Welbat 4. Amnard Chaichun 5. Kittisak Sripanidkulchai 6. Bungorn Sripanidkulchai |
| Title | Effects of aged garlic extract on spatial memory and oxidative damage in the brain of amyloid-? induced rats |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2562 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 41 |
| Journal No. | 2 |
| Page no. | 311-318 |
| Keyword | aged garlic extract, hippocampus, Morris water maze, oxidative stress, spatial memory |
| URL Website | http://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | This study investigated the effect of aged garlic extract (AGE) on spatial learning and memory ability using Morris water maze (MWM) test in amyloid-? (A?) induced-neurotoxicity rats. Pretreatment of AGE at oral doses of 125, 250 and 500 mg/kg for 8 weeks significantly prevented the learning and short-term memory impairment in A?-induced neurotoxicity rats. Histological analysis has shown that pretreatment of AGE reversed the neuron loss in the CA1 and CA2 regions of hippocampus of A?-induced neurotoxicity in a comparable effect of ascorbic acid. By DPPH and FRAP determination, AGE had high antioxidative activity. Pretreatment of AGE caused significant increases of superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, no significant change in catalase (CAT) activity, and a significant decrease of malondialdehyde (MDA) level of the A?-induced rat brain homogenate. The results suggest that AGE ameliorates the cognitive dysfunction in A?- induced neurotoxicity rats via its antioxidative effect. |
