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Investigation of biodegradable chitosan nanoparticlesincorporated with Gd-DTPA prepared by ionotropic gelationfor magnetic resonance imaging |
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| รหัสดีโอไอ | |
| Creator | 1. Waralee Watcharin 2. Suchawadee Wiratthikowit |
| Title | Investigation of biodegradable chitosan nanoparticlesincorporated with Gd-DTPA prepared by ionotropic gelationfor magnetic resonance imaging |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2562 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 41 |
| Journal No. | 6 |
| Page no. | 1396-1403 |
| Keyword | nanoparticles, chitosan, Gd-DTPA, MRI contrast agent |
| URL Website | http://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | A nanoparticle based magnetic resonance imaging (MRI) contrast agent was studied using the biopolymer chitosan.(Gd-DTPA)-conjugated chitosan nanoparticles were prepared by a one-step ionotropic gelation method at chitosan concentrationsof 0.5 and 1.0 mg/mL. The nanoparticles were characterized by scanning electron microscopy and the particle size, zeta potential,and polydispersity index (PDI) were measured by dynamic light scattering. The results showed that (Gd-DTPA)-conjugatedchitosan nanoparticles were homogeneous and the size had a narrow distribution based on the PDI which was in the range of 0.10.3. The mean?SD of the Gd content was found to be 6.2?1.5 mg/g particle. The in vitro release study along with UV-vis spectrashowed no free Gd ions released from the prepared nanoparticles. The results confirmed that the binding of Gd-DTPA to chitosandid not exert any influence on the nanoparticle size or zeta-potential. |
