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Quercetin improves survival rate of cisplatin-induced acutenephrotoxicity: A renal clearance and histopathological study |
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| รหัสดีโอไอ | |
| Creator | 1. Paradorn Muangnil 2. Nawiya Huipao 3. Pornpimol Kirirat 4. Siriphun Hiranyachattada |
| Title | Quercetin improves survival rate of cisplatin-induced acutenephrotoxicity: A renal clearance and histopathological study |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2561 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 40 |
| Journal No. | 3 |
| Page no. | 666 |
| Keyword | quercetin, cisplatin, nephrotoxicity, renal tubular damage, glomerular filtration rate |
| URL Website | http://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | The protective effects of quercetin in cisplatin-induced nephrotoxic rats were investigated. Renal functions usingclearance techniques, histopathological analysis, and the oxidative status were determined on days 3, 7, and 14 after a cisplatin(7.5 mg/kg, intraperitoneal) injection. In cisplatin-treated rats, the survival rate decreased to 59% and 50% on days 7 and 14,respectively. Survived rats had a significant reduction in glomerular filtration rate and an increase in urinary Na+and K+excretion. Histopathological scoring revealed both glomerular and severe tubular damage along with a significant increase inrenal malondialdehyde (MDA) and a reduction in catalase activity. Oral administration of quercetin (50 mg/kg, twice at 24 h and10 min before cisplatin injection) not only increased the survival rate to 75% but also suppressed the elevation of renal MDA andimproved both glomerular and tubular function. The responsible mechanism of the renal protection by quercetin may be via itsantioxidant properties. |
