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Optimal doses and neuroprotective effects of prolonged treatmentwith young coconut juice in orchidectomized rats. A preliminary study |
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| รหัสดีโอไอ | |
| Creator | 1. Tatcha Balit 2. Asma Asae 3. Piyakorn Boonyoung 4. Kanyaphak Chanchula 5. Phetai Hiranphan 6. Thammarat Panityakul 7. Nisaudah Radenahmad |
| Title | Optimal doses and neuroprotective effects of prolonged treatmentwith young coconut juice in orchidectomized rats. A preliminary study |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2561 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 40 |
| Journal No. | 2 |
| Page no. | 475 |
| Keyword | young coconut juice, Cocos nuciferaL., Arecaceae, cresyl violet staining, orchidectomy, serum chemical analysis |
| URL Website | http://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | Our previous studies showed that feeding of young coconut juice (YCJ) had beneficial effects in both male and femalerats such as preventing osteoporosis, accelerating wound healing and delaying Alzheimer's disease (AD) pathologies. Nevertheless,this large dose of YCJ feeding for five weeks in female rats started to have unfavorable side effects e.g. the deposition of glycogenin the liver. Thus, our aim in the present study was to investigate the lowest neuroprotective dose of YCJ that would cause theleast side effects for long-term consumption in male rats. Three low doses of YCJ (10, 20 and 40 mL/kg body weight (BW)wereapplied. The results showed that YCJ preserved the number of neuronal cells but to different degrees in each area of the brain.After 10 weeks of treatment, the BW and organ weights (liver, kidney and adrenal gland) of the three YCJ treated groups were notsignificantly different from the control group. Moreover, the circulating levels of blood sugar, cholesterol, triglyceride, HDL, BUN,creatinine, total protein, albumin, AST, ALT, alkaline phosphatase, sodium, calcium, phosphorus and magnesium of the three YCJtreatments were not significantly different from the sham group. These results indicated that YCJ consumption might have potentialto be a supplement for preserving neuronal cell density and was safe in terms of lipid, liver and renal profiles. |
