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Gastroprotective effects of methanolic extract of kratom leaveson gastric ulcer and reflux esophagitis in rats |
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| รหัสดีโอไอ | |
| Creator | 1. Somsmorn Chittrakarn 2. Nisaudah Radenahmad 3. Sujitra Kaewsara 4. Wandee Udomuksorn 5. Niwat Keawpradub 6. Pimpimol Phukpattaranont |
| Title | Gastroprotective effects of methanolic extract of kratom leaveson gastric ulcer and reflux esophagitis in rats |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2561 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 40 |
| Journal No. | 2 |
| Page no. | 258 |
| Keyword | Mitragyna speciosa (Korth.) Havil., kratom, gastric ulcer, reflux esophagitis, mitragynine |
| URL Website | http://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | Kratom (Mitragyna speciosa (Korth.) Havil.) is a tropical tree indigenous to Thailand. In traditional medicine, it hasbeen used to treat diarrhea, peptic ulcer, stomach ache or gastric upsets. In this study, the protective effects of a methanolicextract of kratom leaves on peptic ulcer models and reflux esophagitis in rats were studied. A methanolic extract of kratom leavesat a dose of 200 and 400 mg/kg were tested in rats on three induced peptic ulcer models and reflux esophagitis. The peptic ulcermodels were induced by water immersion restraint (WIR) stress, alcohol treatment, and acetylsalicylic treatment. The methanolicextract of mitragynine from kratom leaves and ranitidine decreased the ulcer index significantly in the WIR stress model.Conclusion: Only 400 mg/kg of methanolic extract of kratom leaves and omeprazole decreased the ulcer index in the alcohol andacetylsalicylic acid induced ulcer models. No protective effect of kratom extract was found on the reflux esophagitis model. |
