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Antioxidative and melanin production inhibitoryeffects of Syzygium cumini extracts |
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| รหัสดีโอไอ | |
| Creator | 1. Jintana Junlatat 2. Niramai Fangkrathok 3. Bungorn Sripanidkulchai |
| Title | Antioxidative and melanin production inhibitoryeffects of Syzygium cumini extracts |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2561 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 40 |
| Journal No. | 5 |
| Page no. | 1136-1143 |
| Keyword | Syzygium cumini, tyrosinase, melanin, B16-F10 cells |
| URL Website | http://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | Syzygium cumini (L.) Skeels is a famous herbal tree in Myrtaceae family. Antioxidative activity of its ethanolic extractwas determined using DPPH assay and the result showed that S. cumini leaf extract (SLE) exhibited stronger antioxidativeproperties than its branch extract (SBE) with IC50 values at 4.58?0.07 and 5.80?0.03 ?g/mL, respectively. Moreover, both SLEand SBE revealed high total phenolic contents which were related to their antioxidative activities. In addition, inhibition ofmelanin production was assessed in B16-F10 murine melanoma cells. After 48 hr of incubation at concentrations between 0.06-1.00 mg/mL, cells exhibited no toxicity and inhibited melanin production. RT-PCR analysis indicated the extracts inhibited theexpression of tyrosinase, tyrosinase-related protein (TRP)-1 and TRP-2 genes in a dose-dependent manner. The findings revealthe antioxidative and melanin production inhibitory properties of the S. cumini extracts. In particular, SLE should be furtherdeveloped for skin whitening products. |
