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Predicting the duration of antimalarial treatment with heme degradationinhibitors of blood schizonticides using mathematical models |
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| รหัสดีโอไอ | |
| Creator | 1. Panit Suavansri 2. Nataphan Kitisin |
| Title | Predicting the duration of antimalarial treatment with heme degradationinhibitors of blood schizonticides using mathematical models |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2561 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 40 |
| Journal No. | 5 |
| Page no. | 1115-1124 |
| Keyword | malaria, death rate, probability |
| URL Website | http://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | A mathematical model of the death rate of malaria parasite due to the antimalarial drugs is established in this paper topredict the treatment duration and the drug dosage. This model is based on probabilities, pharmacokinetics and pharmacodynamics(PK/PD), biology, medical sciences, theoretical physics and chemistry. The death rate of malaria parasite is derivedfrom the flow rates of drug molecules to the malaria parasite by using the theory of blood convection and probabilities. Using themalaria model, numerical results are generated. In conclusion, the numerical estimate of treatment duration from our modelranges from 1 to 10 days, conforming to actual clinical data. |
