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Effect of chitosan scaffold on bone healing in rabbit calvarial defect |
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| รหัสดีโอไอ | |
| Creator | 1. Thongchai Nuntanaranont 2. Bounthone Bounmanatham 3. Suttatip Kamolmatyakul |
| Title | Effect of chitosan scaffold on bone healing in rabbit calvarial defect |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2561 |
| Journal Title | Songklanakarin Journal of Science and Technology |
| Journal Vol. | 40 |
| Journal No. | 4 |
| Page no. | 792 |
| Keyword | boneformation, chitosan, scaffold |
| URL Website | http://rdo.psu.ac.th/sjstweb/index.php |
| ISSN | 0125-3395 |
| Abstract | The aim of this study was to evaluate the effect of 3D 2% w/v chitosan scaffolds on new bone formation in a rabbitcalvarial defect. Two bi-cortical skull defects were prepared in 16 male rabbits and divided into two groups: autogenous (positivecontrols) and chitosan scaffolds (experimental groups). The animals were sacrificed at 2, 4, 8, and 12 weeks. New boneformation was evaluated by micro-CT and histomorphometric analysis. The positive control group demonstrated significantlygreater bone formation. The experimental groups showed viable lamellar bone with osteoblasts forming bone from the defectmargin. Histomorphometric analysis showed an increased percentage of new bone formation over time, and a micro-CT analysisalso showed an increased percentage of bone volume over time. Although the new bone formation was not as good as thepositive control groups, our in-house fabricated chitosan scaffolds presented good biocompatibility and osteoconductiveproperties in a rabbit calvarial defect. |
