|
Gastroprotective effect of hydroalcoholic extract of Ocimum africanum leaves |
|---|---|
| รหัสดีโอไอ | |
| Creator | 1. Jaruwat Bunwijit 2. Bungorn Sripanidkulchai 3. Wanassanun Pannangrong 4. Jintana Junlatat 5. Kittisak Sripanidkulchai |
| Title | Gastroprotective effect of hydroalcoholic extract of Ocimum africanum leaves |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2560 |
| Journal Title | Songklanakarin Journal of Science and Technology (SJST) |
| Journal Vol. | 39 |
| Journal No. | 4 |
| Page no. | 539 |
| Keyword | gastroprotection,acid/alcohol-induced gastric lesion,Ocimum africanum,antioxidation,superoxide dismutase,catalase,glutathione peroxide |
| ISSN | 0125-3395 |
| Abstract | Ocimum africanum Lour. (hairy basil, hoary basil or lemon basil) is an aromatic herb in Asian and Thai cuisine that hasbeen used as a carminative, a digestion enhancement and remedy for gastrointestinal disturbance in Thai traditional medicine.This study was performed to evaluate the gastroprotective effect of O.africanum leaf extract in acid/alcohol-induced gastriclesion in rats. Pretreatment of the plant extract can prevent the gastric damage in a dose-dependent manner. At 125 mg/kg ofbody weight, the plant extract attenuated the inflammation with % ulcer index of 5.08?1.41, whereas at doses of 250 and 500mg/kg of body weight, the gastric lesion was completely prevented in the manner similar to what was observed in omeprazolepretreated animals (% ulcer index of 1.0?61.94, 0.1?10.45 and 0.00?0.00, respectively). The protective effect of the plantextract against acid/alcohol-induced gastric damage relates to its high antioxidative property and the ability to enhance theactivities of three antioxidative enzymes, i.e. superoxide dismutase, catalase and glutathione peroxidase. Preliminaryphytochemical investigation demonstrated that certain phenolic compounds such as rosmarinic acid, caffeic acid and vanillicacid might take part in the protective effects. |
