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Cytotoxicity of clerodane diterpenoids from fresh ripe fruitsof Casearia grewiifolia |
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| รหัสดีโอไอ | |
| Creator | 1. Thanesuan Nuanyai 2. Benjamat Chailap 3. Anumart Buakeaw 4. Songchan Puthong |
| Title | Cytotoxicity of clerodane diterpenoids from fresh ripe fruitsof Casearia grewiifolia |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2560 |
| Journal Title | Songklanakarin Journal of Science and Technology (SJST) |
| Journal Vol. | 39 |
| Journal No. | 4 |
| Page no. | 517 |
| Keyword | Casearia grewiifolia,clerodane diterpenoids,cytotoxicity |
| ISSN | 0125-3395 |
| Abstract | A new clerodane diterpene, Caseargrewiin M (1), and one known compound (2) were isolated from fresh ripe fruits ofCasearia grewiifolia. The structures of all isolated compounds were evaluated on the basic 1D (1H and 13C) and 2D NMR(COSY, HSQC, HMBC and NOESY) spectral data. All compounds were examined cytotoxicity with five human cancer celllines, Hep-G2 (hepatocarcinoma), SW620 (colon adenocarcinoma), Chago-K1 (undifferentiated lung carcinoma), KATO-III(gastric carcinoma), and BT474 (breast ductal carcinoma). Isolated compounds showed broad cytotoxicity against five humancancer cell lines with IC50 values between 0.906.30 ?g/mL. |
