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In vivo and in vitro antidiabetic effects of Clerodendrum longisepalum |
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| รหัสดีโอไอ | |
| Creator | 1. Supat Phaopongthai 2. Jirapast Sichaem 3. Jatuporn Phaopongthai |
| Title | In vivo and in vitro antidiabetic effects of Clerodendrum longisepalum |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2560 |
| Journal Title | Songklanakarin Journal of Science and Technology (SJST) |
| Journal Vol. | 39 |
| Journal No. | 3 |
| Page no. | 317 |
| Keyword | Clerodendrum longisepalum,diabetic rats,?-glucosidase inhibitory activity,antioxidant activity |
| ISSN | 0125-3395 |
| Abstract | This study aimed to investigate the antidiabetic properties of Clerodendrum longisepalum. This primary screeningstudy focused on blood glucose levels and hematological values in diabetic rats treated with the leaf extract fromC. longisepalum (CL). Results showed that the CL extract can lower the blood glucose level of the experimental animals fromthe diabetic state. In relation to this, the extract caused the hematological value in diabetic rats to drop close to normalcontrols. However, the in vitro ?-glucosidase assay-guided isolation revealed that the stem extract of C. longisepalum hasa possible connection with the inhibition of intestinal ?-glucosidase. Three triterpenoids (1-3), one glycerol derivative (4) aswell as six phenylpropanoid glycosides (5-10) were isolated. Compound 10 possessed good anti-?-glucosidase activity(maltase). A kinetic investigation of 10 indicated that it retarded maltase function in a noncompetitive manner. Moreover,compounds 6, 9 and 10 also showed good antioxidant activity (DPPH). |
