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Nuclear magnetic resonance spectroscopy based metabolomicsto identify novel biomarkers of alcohol-dependence |
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| รหัสดีโอไอ | |
| Creator | 1. Hamza Mostafa 2. Arwa M. Amin 3. Nor Hayati Arif 4. Vikneswaran a/l Murugaiyah 5. Baharudin Ibrahim |
| Title | Nuclear magnetic resonance spectroscopy based metabolomicsto identify novel biomarkers of alcohol-dependence |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2560 |
| Journal Title | Songklanakarin Journal of Science and Technology (SJST) |
| Journal Vol. | 39 |
| Journal No. | 2 |
| Page no. | 153 |
| Keyword | alcohol-dependence,diagnosis,metabolomics,metabotype,nuclear magnetic resonance |
| ISSN | 0125-3395 |
| Abstract | Alcohol misuse is a ravaging public health and social problem. Its harm can affect the drinkers and the whole society.Alcohol-dependence is a phase of alcohol misuse in which the drinker consumes excessive amounts of alcohol and has acontinuous urge to consume alcohol. Current methods of alcohol dependence diagnoses are questionnaires and some biomarkers.However, both methods lack specificity and sensitivity. Metabolomics is a scientific field which deals with the identificationand the quantification of the metabolites present in the metabolome using spectroscopic techniques such as nuclearmagnetic resonance (NMR). Metabolomics helps to indicate the perturbation in the levels of metabolites in cells and tissuesdue to diseases or ingestion of any substances. NMR is one of the most widely used spectroscopic techniques in metabolomicsbecause of its reproducibility and speed. Some recent metabolomics studies were conducted on alcohol consumptionand alcohol misuse in animals and humans. However, few focused on identifying alcohol dependence novel biomarkers.A sensitive and specific technique such as NMR based metabolomics applied to find novel biomarkers in plasma and urinecan be useful to diagnose alcohol-dependence. |
