|
Antibacterial and anti-HIV-1 integrase properties of isolated compoundsfrom Boesenbergia kingii |
|---|---|
| รหัสดีโอไอ | |
| Creator | 1. Teeratad Sudsai 2. Sukanlaya Leajae 3. Nattakan Dangmanee 4. Wasapon Chatgat 5. Prapaporn Chaniad 6. Supinya Tewtrakul |
| Title | Antibacterial and anti-HIV-1 integrase properties of isolated compoundsfrom Boesenbergia kingii |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2560 |
| Journal Title | Songklanakarin Journal of Science and Technology (SJST) |
| Journal Vol. | 39 |
| Journal No. | 1 |
| Page no. | 131 |
| Keyword | Boesenbergia kingii,antibacterial activity,anti-HIV-1 integrase,sesquiterpenes,flavonoids |
| ISSN | 0125-3395 |
| Abstract | Boesenbergia kingii Mood & L.M. Prince, a medicinal plant used to treat infected inflammatory disease was investigatedfor antibacterial and anti-HIV-1 integrase (IN) activities using the broth dilution method and multiplate integrationassay, respectively. Seven compounds were isolated from the active chloroform fraction of B. kingii including 8-hydroxydauca-9,11-diene-7-one(1), dauca-8,11-diene-7-one (2), dauca-8,11-diene-7,10-dione (3), kaempferol-7,4?-dimethyl ether (4),kaempferol-3,7,4?-trimethyl ether (5), dihydrobisdemethoxycurcumin (6) and bisdemethoxycurcumin (7). All of sesquiterpenesmarkedly exhibited the inhibitory activity against Staphylococcus aureus ATCC 29213 and Escherichia coli ATCC 25922.Compound 6 exhibited the highest activity against only S. aureus. However, the most active antibacterial 6 did not inhibitthe activity of HIV-1 IN whereas 7 showed moderate anti-HIV-1 IN and antimicrobial activities. This study demonstrated thatsome compounds found in B. kingii are responsible for anti-bacterial activity and anti-HIV-1 IN. The results of this studysupport the ethnomedicinal uses of B. kingii to some extent. |
