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Anti-inflammatory activity of compounds fromKaempferia marginata rhizomes |
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| รหัสดีโอไอ | |
| Creator | 1. Kanidta Kaewkroek 2. Chatchai Wattanapiromsakul 3. Hisashi Matsuda 4. Seikou Nakamura 5. Supinya Tewtrakul |
| Title | Anti-inflammatory activity of compounds fromKaempferia marginata rhizomes |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2560 |
| Journal Title | Songklanakarin Journal of Science and Technology (SJST) |
| Journal Vol. | 39 |
| Journal No. | 1 |
| Page no. | 91 |
| Keyword | Kaempferia marginata,diterpenes,diarylheptanoid,kavalactone,anti-inflammatory activity |
| ISSN | 0125-3395 |
| Abstract | Two new pimarane diterpenes were obtained from Kaempferia marginata rhizomes, which are 1?-acetoxysandaracopimaradien-2-one(1) and 1?-acetoxysandaracopimaradiene (4), along with seven known compounds from the hexane andchloroform fractions including two pimarane-type diterpenes [marginatol (5), sandaracopimaradiene (8)], one kavalactone[desmethoxyyangonin (3)], three steroids [sitosterol-?-D-glucoside (2), the mixture of stigmasterol and ?-sitosterol (6 + 7)]and one diarylheptanoid [bisdemethoxycurcumin (9)]. Compounds 3 and 9 exhibited potent effect against NO productionwith IC50 of 10.1 and 6.8 ?M, respectively. Compound 3 inhibited iNOS mRNA expression in a dose-dependent manner, while9 suppressed both of iNOS and COX-2 genes. Moreover, compounds 2, 3, 6 + 7 and 9 were isolated for the first time fromK. marginata. These results revealed that diterpenes, diarylheptanoid and kavalactone are components of K. marginata thatafford anti-inflammatory effect through a mechanism involving a decrease in inflammatory mediators. |
