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Beneficial effects of young coconut juice feeding on the lipid,renal and liver profiles, in ovariectomized rats: Preliminary novel findings |
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| รหัสดีโอไอ | |
| Creator | 1. Nisaudah Radenahmad 2. Kitja Sawangjaroen 3. Winyou Mitranun 4. Ibrahim Sayoh |
| Title | Beneficial effects of young coconut juice feeding on the lipid,renal and liver profiles, in ovariectomized rats: Preliminary novel findings |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2559 |
| Journal Title | Songklanakarin Journal of Science and Technology (SJST) |
| Journal Vol. | 38 |
| Journal No. | 1 |
| Page no. | 57-65 |
| Keyword | young coconut juice,liver,kidney,estrogen,lipid |
| ISSN | 0125-3395 |
| Abstract | The purpose of this study was to determine the effects of feeding young coconut juice (YCJ), known to contain ?-sitosterol, to ovariectomized rats, a model for postmenopausal women, on the lipid, renal and liver metabolism profiles. Fourgroups of female rats (6 in each group) were included in this study. These included sham-operated, ovariectomized (ovx),ovx receiving estradiol benzoate (EB) injections intraperitoneally, and ovx receiving YCJ orally. At the end of the third andthe fourth week of study, the rats were sacrificed and their serum estradiol (E2) was analyzed. The uterus was removed alongwith the kidney and liver. The latter was paraffin processed for histopathological assessment. In contast with the 7 daystreatments, all parameters of the 14 days treatment had improved. After 14 days of treatment, the circulating levels of BUN,creatinine, cholesterol, triglyceride, LDL, AST, ALT, ALP, total protein and albumin of ovx+YCJ group were not significantlydifferent from the sham and ovx groups. Only the serum HDL level of the ovx+YCJ group was significantly higher than thatof the sham group. The histopathological assessment of the liver and kidney showed no significant changes when comparedwith the control groups. Glycogen accumulation appeared in the cytoplasm of the hepatocytes particularly in the ovx+YCJgroup but significant changes of the hepatocytes containing glycogen were not detected. No other abnormal features wereseen in any of the four groups. The %age uterine/body weights indicated that YCJ feeding in ovx rats at 100 mL/kgBW forup to two weeks did not cause increased uterine weight. In summary, this study confirmed that feeding YCJ had beneficialeffects on the serum lipid profile, and maintained liver and renal functions for up to 2 weeks after administration. |
