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Clinical and histopathological characteristicsafter subconjunctival implantation of cyclosporine-containingpoly-lactic acid microfilm in normal dogs |
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| รหัสดีโอไอ | |
| Creator | 1. Thanate Anusaksathien 2. Kanjana Imsilp 3. Chaiyan Kasorndorkbua 4. Angkhana Jaroenworaluck 5. Aree Thayananuphat |
| Title | Clinical and histopathological characteristicsafter subconjunctival implantation of cyclosporine-containingpoly-lactic acid microfilm in normal dogs |
| Publisher | Research and Development Office, Prince of Songkla University |
| Publication Year | 2559 |
| Journal Title | Songklanakarin Journal of Science and Technology (SJST) |
| Journal Vol. | 38 |
| Journal No. | 4 |
| Page no. | 421-426 |
| Keyword | cyclosporine,dog,microfilm,poly-lactic acid,subconjunctival implantation |
| ISSN | 0125-3395 |
| Abstract | The objective of the present study was to describe clinical signs and histopathology of the conjunctiva after subconjunctivalimplantation with poly-lactic acid microfilm (PLA-M) and cyclosporine-containing PLA microfilm (CsPLA-M) inseven healthy dogs. A randomized, double-blind implantation of a PLA-M and CsPLA-M was performed in each eye. Ocularclinical signs and Schirmer tear test (STT) levels were determined on days 1, 3, 7, 14, 28, 60 and 90 after implantation. Allimplanted eyes had conjunctival hyperemia after implantation which eventually resolved within 90 days. Histopathologicalexamination of conjunctival biopsy showed mild inflammatory cell infiltration. There was no significant statistical differenceof conjunctival hyperemia scores, STT values or histopathological scores between the two groups. All devices remainedunder subconjunctiva at 90 days after implantation. These results suggested that the device was safe and well tolerated forsubconjunctival implantation in dogs. |
